Wolverine has five Combat Reflexes, which all have three levels. You improve your level by beating enemies that fit in the type of reflex. The five reflexes are:
- Machete (any enemy with a machete): Replay Level 1.1 or Level 5.1
- Machine Gunner (any enemy with a gun): Replay Level 4.3
- Jungle Mutants (Hunters, Shifters, Leviathans): Replay Level 5.1
- Robots (Enforcer Droid, Predator Unit, Mark 1 Prototype): Replay Level 3.2
- Specialized Military Units (Elite Commandos, Goliaths, W.E.N.D.I.G.0 Prototypes, Ghosts, Grenadiers): - Replay Level 4.3
Once you find the Samurai Mutagen make sure to equip this, as this advances your reflexes faster. Make sure to find all three to max out the increase.