Story related, can't be missed.
This is basically the boss of Act 1. Attack with normal combo attacks and when Anti-Venom is about to attack, just activate . If you apply this basic method through the entire fight, you should have no trouble with this boss. When he is hurt enough you will have to run to him and tap . There will be a point when you end up in another room and have to help the normal Spider-Man out by destroying some things. Here, Anti-Venom takes no damage. Just have him charge at you while you are in front of one of the freezing chambers. Hit to evade and he will destroy them. Once enough is destroyed, you will continue the fight like normal but a new attack is involved from Anti-Venom. Don't worry, use the same tactics as before. This is a very easy fight since your stamina refills so quickly.