You should always have some healing items on you as a priority, since you can always run away and heal up if you need to, and it's also important to keep some distance between yourself and every new enemy you encounter to learn how they move. Some enemies are capable of cutting you down in one attack (such as the Scagdead or Farfarello while invisible), while some of the bosses can be frustrating if you don't know what you're doing, so I would recommend watching videos for those if you're uncomfortable with winging it yourself. Most players, especially seasoned RE veterans, should have a good chance of getting this on at least Normal difficulty, while those familiar with the game already shouldn't have much trouble at all. Doing this on Infernal difficulty is recommended only for masochists, however it can actually make you go through the game on the edge of your seat.
When/if you die, DO NOT hit "yes" to continue, instead hit "no" and you'll be sent back to the main menu. From there, you can hit continue to load up your most recent checkpoint and go about your business until you die again, then rinse and repeat. This process will result in 0 deaths in the Episode summary screens, which is what tells you whether you'll get the achievement or not. Thanks ss4goku2425 for confirming.