Use your DP points to unlock all of the Player Upgrades in the upgrade menu. By the time you've completed a playthrough, you should have most of the upgrades completed already. TIP: If you find a spot where you are getting a lot of DP points and there is a check point close before, you can buy an upgrade and reload the check point and farm the DP points again. The game won't save your DP points unless you purchase an upgrade. I found several good farming spots throughout the game to keep upgrading/reloading. The part where you visit the 3 Deadpoolios on the "Death, Baby" stage and the door breach section during the "Road to Victor" stage are some examples.