|Perform an Air Assassination on a Poisoned NPC.|
This can be done after taking the codex to you receive from Lorenzo to Leonardo in the mission "A Blade With Bite". First, try to find a patrol of guards, and an area with enough height to do a jumping assassination from. Wait until the guards get near the area, and then poison one of them. After that's done, climb up to whatever area you picked out, lock onto the poisoned guard (he'll be the one beginning to go crazy) and assassinate him.
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