Originally Posted by Son of Kyuss
Yes, I left all the homestead missions until I had completed the game.
...but I won't recommand that.
If you leave the homestead missions 'til the end, then you won't be able to scan your people for the encyclopedia of the comman man whenever you visit the Homestead while progressing in the story.
And I suppose then it'll take longer for you to scan everyone, especially because these Homestead-people really only do shit if you keep following them around.