Worth playing through multiple times?
 

There are two kinds of games, as far as I'm concerned -- games that are only tolerable once (so you must collect all achievements through your one-and-only playthrough), and games that you can play through several times (so you can do the first for fun, without worrying about achievements, another achievement-driven playthrough, and another cleanup playthrough if necessary).

Which type is this?

I've tried to do everything at once -- overwhelming.
I've tried to just play -- worried about replayability.

So, is it worth playing through it for fun before worrying about achievements? Will the replay be a drag?

It can all be done in two runs and still be very fun.

I played the game back to back 3 times, found it to be an enjoyable experience but was getting to be a drag by the end of 3. The only reason I played a 3rd run was because I missed some audio diaries and research on my first runs.

This is by far one of the most entertaining games I´ve ever played...
I can play this again without a problem for collectibles and missed achievements (although I got it all at once) even as I know the plot and it´s twists....

The only issue I can see would be to play this again and again on a row if you miss a collectible you can´t get back to.

it depends if you like to play games over again tbh. some games are easy to play over again becuase you can change things up like bioshock. i play them over again for the achievments and for the thrills.

I've played through Bioshock more times than I can tally, and I can tell you, it never got old.

I've played the game about five times from start to finish.
Look forward to playing it about ten more times for more achievements and trophies.

My second favorite game this gen, defiantly in my top ten of all time.

Fun to Replay
 

It is really overwhelming to try to do everything first run, and sucks the fun right out of the game. I actually think this game is MORE fun the more you play it. I mean some of the "surprise" story element is gone, but seeing as it's an older game some of that is probably gone for you anyway lol. It's not a long game imho (especially when replaying), most of the achievements unlock without a thorough grind, so play for fun first and then see what you need to get. Totally replayable.